PENGARUH PEMBERIAN EKSTRAK AKAR ALANG-ALANG (Imperata cylindrica L. Raeusch.) TERHADAP KADAR GLUKOSA PADA TIKUS PUTIH JANTAN (Rattus norvegicus) KOMPLIKASI DISFUNGSI GINJAL
DOI:
https://doi.org/10.62710/npp0ww87Keywords:
Alang- Alang, Diabetes Melitus, Disfungsi Ginjal, Glukosa Darah, KreatininAbstract
Diabetes melitus dapat menimbulkan disfungsi ginjal, dan akar alang-alang (Imperata cylindrica (L.) Raeusch.) mengandung flavonoid serta saponin yang berpotensi antihiperglikemik. Penelitian ini bertujuan menguji pengaruh ekstrak etanol akar alang-alang terhadap dua parameter, yaitu kadar glukosa darah dan kreatinin serum, pada tikus putih jantan (Rattus norvegicus) diabetes dengan komplikasi disfungsi ginjal. Penelitian eksperimental dengan Randomized Control Group Design ini menggunakan 36 ekor tikus dalam enam kelompok. Diabetes diinduksi dengan aloksan 150 mg/kgBB dan disfungsi ginjal dengan gentamisin 80 mg/kgBB, kemudian ekstrak dosis 200, 400, dan 800 mg/kgBB diberikan selama 14 hari. Glukosa darah dianalisis dengan Two-Way Repeated Measures ANOVA dan kreatinin dengan uji Kruskal–Wallis. Dari hari ke-0 ke hari ke-14, glukosa darah kelompok dosis 200, 400, dan 800 mg/kgBB turun dari 372 ± 32,14 menjadi 120 ± 35,59 mg/dL, dari 453,3 ± 4,50 menjadi 102,3 ± 17,03 mg/dL, dan dari 459,6 ± 23,35 menjadi 57,66 ± 8,38 mg/dL (p < 0,001), tanpa perbedaan bermakna antardosis. Kreatinin serum kelompok uji turun dari 2 ± 0 mg/dL pada hari ke-7 menjadi 1 ± 0 mg/dL pada hari ke-14 (Kruskal–Wallis, p = 0,013), tetapi masih di atas rentang normal. Ekstrak menurunkan glukosa darah, sedangkan aktivitas nefroprotektifnya belum dapat disimpulkan dari data kreatinin saja.
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